Vasodilator 약물 임상연구에 4명의 소년의 참가가 필요하답니다.

근섬유 향상을 위한 새로운 약물인가 봅니다. 정보는 아래와 같습니다.

• 약물 연구는 7 세에서 15 세 사이에 아직 도보가 가능한 Duchenne 근육질 영양 장애 4 명의 참가자를 찾고 있습니다.
• 연구는 두 FDA의 승인을받지 않은 의약품인 tadalafil 및 sildenafil을 이용한 연구이며 이 약품들은 운동하는 동안 혈액의 흐름을 증가하는 근육 섬유의 능력을 향상시킬 수 있습니다.​​
• 참가자는 로스 앤젤레스로 여행을해야합니다, 모든 여행 경비는 포함됩니다.

아래는 원문 입니다.

A 12-participant study of the acute effects of two vasodilating drugs on blood flow to exercising muscles needs four more boys with Duchenne muscular dystrophy (DMD) who meet study criteria and are able to travel to Los Angeles. Vasodilators increase the diameter of blood vessels.

"We’ve made some wonderful progress with our latest Duchenne MD blood flow studies investigating the effects of tadalafil," said Sharon Tang, clinical research coordinator for the study. "In order to complete this exciting project, we only need four more boys. The study only requires one week of study visits in sunny Los Angeles. All travel expenses are covered by the study. Get away from your winter blues and help make us make a difference!"

The study involves taking two doses of each of two drugs — tadalafil and sildenafil — both of which may improve the ability of muscle fibers to increase blood flow during exercise despite the presence of a DMD-causing mutation in the dystrophin gene.

Participants must:

• have a diagnosis of DMD;
• be 7 to 15 years old;
• be able to walk; and
• be without clinical signs of heart failure.

The trial will involve measuring blood flow in exercising forearm muscles and blood medication levels during two sets of visits to Cedars-Sinai Medical Center in Los Angeles, approximately one week apart.

For details, see PDE Inhibitors in DMD (Acute Dosing Study); or enter NCT01580501 in the search box at ClinicalTrials.gov.

Prospective participants should contact Sharon Tang in Los Angeles at (310) 248-8080 or Sharon.Tang@cshs.org.

출처:http://quest.mda.org/news/dmd-vasodilator-drug-study-needs-four-boys