Anti-Cancer 약품은 근육구축에 도움을 줄 수 있을것이다!

• IAP 차단 약물은 암을 치료하는 임상 시험에 근육 생성 또는 myoblast 융합으로 알려진 재생에서 단계를 강화하기 위한 마우스 및 세포 실험에서 발견되었습니다.
• TWEAK (TNF-like weak inducer of apoptosis)이라는 자연적으로 발생한 단백질은 myoblast 융합과 근육 생성 또는 재생을 촉진합니다.
• 안티 - 암 약물은 Duchenne MD 또는 다른 근육 dystrophies의 임상 실험에서 테스트 할 수 있으며, 조정에 대한 연구 결과는 근육 건물 요법의 개발에 대한 추가 단서를 제공 할 수 있습니다.

원문나갑니다.

Experimental anti-cancer drugs that block IAP (inhibitor of apoptosis) genes and kill cancer cells have unexpectedly been found to induce the growth and repair of muscle tissue, say scientists supported in part by MDA.

The results suggest that these drugs, which are already in clinical trials in cancer patients, might be effective in combating muscle degeneration in conditions like Duchenne muscular dystrophy (DMD) and perhaps other muscular dystrophies. The muscle-related experiments were conducted in cells taken from laboratory mice.

The research team, headed by MDA grantee Robert Korneluk at the University of Ottawa and Children's Hospital of Eastern Ontario, published its findings Oct. 16, 2012, in the journal Science Signaling.

The investigators also found that a naturally occurring protein called TWEAK (TNF-like weak inducer of apoptosis) likewise promotes muscle growth and repair, via the same pathway as the anti-cancer drugs. The TWEAK findings shed additional light on the mechanisms underlying muscle growth and repair, and could provide researchers with additional leads toward therapies.

Specifically, the anti-IAP drugs and the TWEAK protein enhance the fusion of muscle precursor cells called myoblasts into myotubes, which are early-stage muscle fibers. Myoblast fusion is an essential step in the formation and regeneration of muscle.

"We know of five pharmaceutical companies pursuing phase 1 clinical trials with specific [IAP-targeting] drugs to treat cancer patients," Korneluk said in an Oct. 16 press release from Children's Hospital of Eastern Ontario (CHEO).

Eric LaCasse, a study author at CHEO, added that he thought the IAP-targeting drugs could be tried in a muscle disease soon. "We think it's reasonable to move into clinical trials with this methodology within the next couple of years," he said. "Regulatory bodies need proof that the drug is safe, which the existing cancer trials will offer, and they need to see an evidence-based rationale — which we've worked hard to be able to announce today."

MDA is exploring several strategies to fight muscle degeneration, including blocking a protein called myostatin, increasing blood flow to exercising muscles, and developing anti-inflammatory compounds that mimic the benefits but not the side effects of corticosteroids like prednisone.

출처:http://quest.mda.org/news/anti-cancer-drugs-may-help-build-muscle